Mast Cell Peptidases

Mast Cell Leukemia with Ascites and Multiple Organs Damage

Mast Cell Leukemia (MCL), a rare subtype of systemic mastocytosis is defined by bone marrow involvement as atypical and aleukemic mast cells, if more than 20% and less than 10% of peripheral WBCs are mast cells, respectively. We met a case of aleukemic MCL presenting with anemia and ascites for 2 years, referred for BM evaluation, suspicious of leukemia. Our findings included BM involveme...

INFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION

In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...

Mast cells and histopathologic variants of basal cell carcinoma

Background and aim: The stroma of basal cell carcinoma (BCC) is rich in mast cells. Morpheaform BCC has been reported to contain much more mast cells than the other types of BCC, but their significance remains unknown. In this study we investigated the significance of mast cells related to BCC and possible relationship between increased number of mast cells and clinical and histological p...

Mast Cell and Tryptases Changed Rapidly during Primate Speciation and Evolved from -Like Transmembrane Peptidases in Ancestral Vertebrates

Of peptides and peptidases: the role of cell surface peptidases in cancer.

Introduction The renin-angiotensin system has been studied for over three decades in relation to cardiovascular and renal physiology. Angiotensin II (Ang II), the central product of the renin-angiotensin system, functioning through the Ang II type 1 receptor has been shown to exert numerous effects, including stimulating cell growth, inducing gene expression of various growth factors (i.e., bas...